top of page
Rational RNA Therapeutics
The biggest obstacle to creativity is breaking through the barrier of disbelief.
Recent successes in the clinic have demonstrated that RNA can be used to effectively treat and prevent human disease. We are using our intimate knowledge of Argonaute structure and small RNA mechanisms to devise novel RNA-based therapeutics.
Structure-Guided Control of siRNA Off-Target Effects. J Am Chem Soc. 2016 138(28):8667-9.
Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide. J Am Chem Soc. 2016, 138(28):8694-7.
bottom of page