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Protein and RNA Structure

A major strength of the lab is the investigation of biology through molecular form and function. We determine structures of RNA-protein complexes using x-ray crystallography and electron microscopy and combine these results with biochemical and cellular assays that probe molecular mechanisms. Most of our efforts in recent years have been devoted to understanding how Argonaute and Piwi proteins use small RNAs to establish their extraordinary gene-silencing properties.


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